Supports the natural immune defenses of children and the functionality of the upper respiratory tract.

Organic agave syrup, β-glucans extracted from Reishi (Ganoderma lucidum) and Shiitake (Lentinula edodes) mushrooms titrated >30% in polysaccharides, Propolis M.E.D.^® hydroalcoholic extract standardized in polyphenols, gemmotherapeutics of Blackcurrant buds (Ribes nigrum), Rosehip young shoots (Rosa canina), Blackthorn buds (Prunus spinosa); strawberry flavor, lactic acid, potassium sorbate, sodium benzoate

10 ml daily preferably away from meals, during the cold season and during seasonal changes. Shake before use

• Gluten-free
• Registered in the supplements registry: code 165145
• EAN code: 8059173430277 – Paraf. Code 986871806

Propolis MED
• Sevda Demir, Ali Timucin Atayoglu, Fabio Galeotti, Emanuele U Garzarella, Vincenzo Zaccaria, Nicola Volpi, Ali Karagoz, Fikrettin Sahin Antiviral activity of different extracts of standardized propolis preparations against HSV. Antivir Ther. 2020;25(7):353-363.
• Cristina Esposito, Emanuele Ugo Garzarella, Bruno Bocchino, Maria D’Avino, Giuseppe Caruso, Antonio Riccardo Buonomo, Roberto Sacchi, Fabio Galeotti, Gian Carlo Tenore, Vincenzo Zaccaria, Maria Daglia. A standardized polyphenol mixture extracted from poplar-type propolis for remission of symptoms of uncomplicated upper respiratory tract infection (URTI): A monocentric, randomized, double-blind, placebo-controlled clinical trial. Phytomedicine 80 (2021) 153368
• Vincenzo Zaccaria, Emanuele Ugo Garzarella, Carmen Di Giovanni, Fabio Galeotti, Lucia Gisone, Davide Campoccia, Nicola Volpi, Carla Renata Arciola and Maria Daglia. Multi Dynamic Extraction: An Innovative Method to Obtain a Standardized Chemically and Biologically Reproducible Polyphenol Extract from Poplar-Type Propolis to Be Used for Its Anti-Infective Properties. Materials 12, 3746, 2019.
• Valeria Curti, Vincenzo Zaccaria, Arold Jorel Tsetegho Sokeng, Marco Dacrema, Irene Masiello, Anna Mascaro, Giuseppe D’Antona, and Maria Daglia. Bioavailability and In Vivo Antioxidant Activity of a Standardized Polyphenol Mixture Extracted from Brown Propolis. Int J Mol Sci. 2019 Mar; 20(5): 1250.
• Sevda Yuksel and Sumeyya Akyol. The consumption of propolis and royal jelly in preventing upper respiratory tract infections and as dietary supplementation in children. J Intercult Ethnopharmacol. 2016 Jun-Aug; 5(3): 308–311.

Beta glucans
• Josef Richter, Vladimir Svozil, Vlastimil Král, Lucie Rajnohová Dobiášová, and Vaclav Vetvicka. β-glucan affects mucosal immunity in children with chronic respiratory problems under physical stress: clinical trials. Ann Transl Med. 2015 Mar; 3(4): 52.
• Rachana Bhoite, Vinita Satyavrat, and Manasa Premasudha Sadananda. Clinical benefits of β-glucan supplementation in children: a review. Discov Food. 2022; 2(1): 37.
• Milos Jesenak, Juraj Majtan, Zuzana Rennerova, Jan Kyselovic, Peter Banovcin, Martin Hrubisko. Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Int Immunopharmacol. 2013 Feb;15(2):395-9
• Elena De Marco Castro, Philip C. Calder, and Helen M. Roche. ????-1,3/1,6-Glucans and Immunity: State of the Art and Future Directions. Mol. Nutr. Food Res. 2021, 65, 190107
• Josef Richter, Vladimir Svozil, Vlastimil Král, Lucie Rajnohová Dobiášová, Ivana Stiborová, Vaclav Vetvicka. Clinical trials of yeast-derived β-(1,3) glucan in children: effects on innate immunity. Ann Transl Med 2014;2(2):15.
• Marigoula Vlassopoulou, Mary Yannakoulia, Vasiliki Pletsa, Georgios Zervakis and Adamantini Kyriacou. Effects of fungal beta-glucans on health – a systematic review of randomized controlled trials.Food Funct., 2021, 12, 3366-3380
• S. L. D. Henao, S. A. Urrego, A. M. Cano and E. A. Higuita, Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with beta-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia, Int. J. Med. Mushrooms, 2018, 20, 705–716.
• Jesenak M, Hrubisko M, Majtan J, Rennerova Z, Banovcin P. Anti-allergic effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Phytother Res. 2014, 28(3):471-4.
Gemmotherapeutics
• Fernando Piterà- Compendium of Clinical Gemmotherapy-De Ferrari Publisher-1994